2024

Drzewiecki CM, Fox AS (2024). Understanding the heterogeneity of anxiety using a translational neuroscience approach. Cognitive, Affective, & Behavioral Neuroscience.

Holley D*, Campos LJ*, Zhang Y, Capitanio JP, Fox AS (2024). Rhesus Infant Nervous Temperament Predicts Peri-Adolescent Central Amygdala Metabolism & Behavioral Inhibition Measured by a Machine-Learning Approach. Translational Psychiatry. 14:148

Tromp DPM, Fox AS, Riedel MK, Oler JA, Zhou X, Roseboom PH, Alexander AL, Kalin NH (2024). Early life adversity in primates: Behavioral, endocrine, and neural effects. Psychoneuroendocrinology. 162, 106953

2023

Kenwood MM, Souaiaia T, Kovner R, Fox AS, French DA, Oler JA, Roseboom PH, Riedel MK, Mueller SAL, Kalin NH (2023). Gene expression in the primate orbitofrontal cortex related to anxious temperament. Proceedings of the National Academy of Sciences. 120 (49) e2305775120

Wright EC, Zakharenkov HC, Godoy AS, Lake A, Prince ZD, Sekar S, Culkin HI, Luo PX, Ramirez AV, Dwyer T, Kapoor A, Corbett C, Tian L, Fox AS, Trainor BC (2023). Sexual differentiation of neural mechanisms of stress sensitivity during puberty. Proceedings of the National Academy of Sciences. 120 (43) e2306475120

Kim HC, Kaplan CM, Islam S, Anderson AS, Piper ME, Bradford DE, Curtin JJ, DeYoung KA, Smith JF, Fox AS, Shackman AJ (2023). Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity. PLoS One. 18(7): e0288544

Chen X, Wolfe DA, Dhanesh Sivadasan Bindu DS, Zhang M, Naz Taskin N, David Goertsen D, Shay TF, Sullivan EE, Huang S-F, Kumar SR, Arokiaraj CM, Viktor M. Plattner VM, Lillian J. Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V (2023). Functional gene delivery to adn across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nature Communicatoins. 14(1):3345

Grogans SE, Bliss-Moreau E, Buss KA, Clark LA, Fox AS, Keltner D, Cowen AS, Kim JJ, Kragel PA, MacLeod C, Mobbs D, Naragon-Gainey K, Fullana MA, Shackman AJ (2023). The Nature and Neurobiology of Fear and Anxiety: State of the Science and Opportunities for Accelerating Discovery. Neuroscience & Biobehavioral Reviews. 151:105237

Campos LJ, Arokiaraj CM, Chuapoco MR, Chen X, Goeden N, Gradinaru V, Fox AS (2023). Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system. Current Research in Neurobiology. 4:100086

Chuapoco MR*, Flytzanis NC*, Goeden N*, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man NKM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich J, Bishaw Y, Gore B, Omstead V, Taskin N, Weed N, Levi BP, Ting J, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V (2023). Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nature Nanotechnology. 18, 1241–1251

Kenwood MM, Oler JA, Tromp DPM, Fox AS, Riedel MK, Roseboom PH, Brunner KG, Aggarwal N, Murray EA, Kalin NH (2023). Prefrontal influences on the function of the neural circuitry underlying anxious temperament in primates. Oxford Open Neuroscience. 2:kvac016

2022

Holley D, Fox AS (2022). Selecting Anxiety: The Central Extended Amygdala as an Arbiter of Emotion-Relevant Responses. Neurobehavioral individual differences - A transdisciplinary approach to advancing clinical science. In Press

Holley D, Fox AS (2022). The central extended amygdala guides survival-relevant tradeoffs: Implications for understanding common psychiatric disorders. Neuroscience & Biobehavioral Reviews. 142:104879

Chen X, Kumar SR, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, Fox AS, Chiu IM, Gradinaru V (2022). Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. Neuron. 110, 1–16

Grogans SE, Fox AS, & Shackman AJ (2022). The Amygdala and Depression: A Sober Reconsideration. American Journal of Psychiatry. 179(7):454–457

Hur J, Kuhn M, Grogans SE, Anderson AS, Islam S, Kim, HC, Tillman RM, Fox AS, Smith JF, DeYoung KA, & Shackman AJ (2022). Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World. Psychological Science. 33(6):906-924

2021

Fox AS, Harris RA, Del Rosso L, Raveendran M, Kamboj S, Kinnally EL, Capitanio JP, Rogers J (2021). Infant Inhibited Temperament in Primates Predicts Adult Behavior, is Heritable, and is Associated with Anxiety-Relevant Genetic Variation. Molecular Psychiatry. 26:6609-6618

Roseboom PH, Mueller SAL, Oler JA, Fox AS, Riedel MK, Elam VR, Olsen ME, Gomez JL, Boehm MA, DiFilippo AH, Christian BT, Michaelides M, Kalin NH (2021). Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders. Molecular Therapy. 29(12):3484-3497

Wang X, Li XH, Cho JW, Russ BE, Rajamani N, Omelchenko A, Ai L, Korchmaros A, Sawiak S, Benn RA, Garcia-Saldivar P, Wang Z, Kalin NH, Schroeder CE, Craddock RC, Fox AS, Evans AC, Messinger A, Milham MP, Xu T (2021). U-Net Model for Brain Extraction: Trained on Humans for Transfer to Non-human Primates. Neuroimage. 235(15):118001

Klink PC, Aubry J-F, Ferrera V, Fox AS, Froudist-Walsh S, Jarray B, Konofagou E, Krauzlis R, Messinger A, Mitchell AS, Ortiz-Rios M, Oya H, Roberts AC, Roe AW, Rushworth MFS, Sallet J, Schmid MC, Schroeder CE, Tasserie J, Tsao D, Uhrig L, Vanduffel W, Wilke M, Kagan I, & Petkov CI (2021). Combined Brain Perturbation and Neuroimaging in Non-human Primates. Neuroimage. 235(15):118017

Poirier C, Hamed SB, Garcia-Saldivar P, Kwok SC, Meguerditchian A, Merchant H, Rogers J, Wells S, Fox AS (2021). Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata.. Neuroimage. 228:117679

Shackman AJ, Fox AS (2021). Two decades of anxiety neuroimaging research: New insights and a look to the future.. American Journal of Psychiatry. 178(2):106-109

Fox AS, Holley D, Klink PC, Arbuckle SA, Barnes CA, Diedrichsen J, Kwok SC, Kyle C, Pruszynski JA, Seidlitz J, Zhou X, Poldrack RA, Gorgolewski KJ (2021). Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault.. Neuroimage. 225:117518

2020

Hur J, Smith JF, DeYoung KA, Anderson AS, Kuang J, Kim HC, Tillman RM, Kuhn M, Fox AS, & Shackman AJ (2020). Anxiety and the neurobiology of temporally uncertain threat anticipation. Journal of Neuroscience. 40 (41) 7949-7964

Kovner R, Souaiaia T, Fox AS, French DA, Goss CE, Roseboom PH, Oler JA, Riedel M, Fekete E, Fudge JL, Knowles JA, Kalin NH (2020). Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early Life Anxious Temperament. Biological Psychiatry. 88(8):638-648

The PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium (2020). Accelerating the Evolution of Nonhuman Primate Neuroimaging. Neuron. 105(4):600-603

2019

Fox AS*, Souaiaia T*, Oler JA, Kovner R, Mun J, Nguyen J, French DA, Riedel M, Fekete E, Rabska MR, Olsen ME, Brodsky EK, Alexander AL, Block WF, Roseboom PH, Knowles JA, Kalin NH (2019). Dorsal amygdala neurotrophin-3 decreases anxious temperament in primates. Biological Psychiatry. 12(15):881-889

Tromp DPM, Fox AS, Oler JA, Alexander AL, Kalin NH (2019). The Relationship Between the Uncinate Fasciculus and Anxious Temperament Is Evolutionarily Conserved and Sexually Dimorphic. Biological Psychiatry. 12(15): 890-898

Golub MS, Hogrefe CE, Campos LJ, Fox AS (2019). Serotonin transporter (SERT) binding potentials in brain of juvenile monkeys one year after discontinuation of a two-year treatment with fluoxetine. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4(11): 948–955

Hur J, Stockbridge MD, Fox AS, Shackman AJ (2019). Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework. Progress in Brain Research. 247

Tromp DPM, Williams LE, Fox AS, Oler JA, Roseboom PH, Rogers GM, Benson BE, Alexander AL, Pine DS, Kalin NH (2019). Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders is Altered in Boys but not Girls. American Journal of Psychiatry. 176(3):208-216

Kovner R, Fox AS, French DA, Roseboom PH, Oler JA, Fudge JL, Kalin NH (2019). Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala. Neuroscience. 400:157-168

Fox AS*, Shackman AJ* (2019). The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research. Neuroscience Letters. 693:58-67

Heller AS, Fox AS, Davidson RJ (2019). Parsing Affective Dynamics to Identify Risk for Mood and Anxiety Disorders. Emotion. 19(2):283-291

Hur J, Tillman RM, Fox AS, Shackman AJ (2019). The value of clinical and translational neuroscience approaches to psychiatric illness. Behavioral and Brain Sciences. 42, e11

2018

Hur J, Kaplan CM, Smith JF, Bradford DE, Fox AS, Curtin JJ, Shackman AJ (2018). Acute alcohol administration dampens threat-related activation in the central extended amygdala. Scientific Reports. 12;8(1):16702

Fox AS*, Oler JA*, Birn RM, Shackman AJ, Alexander AL, & Kalin, NH (2018). Functional connectivity within the primate extended amygdala is heritable and associated with early-life anxious temperament. Journal of Neuroscience. 29;38(35):7611-7621

Shackman AJ*, Fox AS* (2018). Getting Serious about Variation: Lessons for Clinical Neuroscience (A Commentary on The Myth of Optimality in Clinical Neuroscience). Trends in Cognitive Sciences. 22(5):368-369

Tillman RM, Stockbridge MD, Nacewicz BM, Torrisi S, Fox AS, Smith JF, Shackman AJ (2018). Intrinsic functional connectivity of the central extended amygdala. Human Brain Mapping. 39(3):1291-1312

Fox AS (2018). The brain is organized to emote. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

Shackman AJ, Weinstein J, Hudja SN, Bloomer C, Barstead MG, Fox AS & Lemay EP, Jr. (2018). Dispositional negativity in the wild: Social context governs momentary emotional experience. Emotion. 18(5):707-724

2017

Shackman AJ*, Fox AS*, Oler JA, Shelton SE, Oakes TR, Davidson RJ, & Kalin, NH (2017). Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Molecular Psychiatry. 22(5):724-732

Oler JA*, Tromp DPM*, Fox AS, Kovner R, Davidson RJ, Alexander AL, MacFarlin D, Birn R, Berg B, de Campo D, Fudge JL, & Kalin NH (2017). Brain Structure and Function. . 222(1):21-39

2016

Shackman AJ*, Fox AS* (2016). Contributions of the central extended amygdala to fear and anxiety. Journal of Neuroscience. 36(31):8050-8063

Shackman AJ, Tromp DPM, Stockbridge MD, Kaplan CM, Tillman RM, & Fox AS (2016). Dispositional negativity: An integrative psychological and neurobiological perspective. Psychological Bulletin. 142(12):1275-1314

Kalin NH, Fox AS, Kovner R, Riedel MK, Feketa EM, Roseboom PH, Tromp DPM, Grabow BP, Brodsky EK, Olsen ME, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA (2016). Overexpressing Corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit. Biological Psychiatry. 80(5):345-55

Oler JA, Fox AS, Shackman AJ, Kalin NH (2016). The Central Nucleus of the Amygdala is a Critical Substrate for Individual Differences in Anxiety. Living without an amygdala (Amaral DG, Bauman M, & Adolphs R, Eds.). Guilford Press. 2016

Oler JA*, Tromp DPM*, Fox AS, Kovner R, Davidson RJ, Alexander AL, MacFarlin D, Birn R, Berg B, de Campo D, Fudge JL, & Kalin NH (2016). Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Structure and Function. 222(1):21-39

2015

Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander AL, Davidson RJ, Blangero J, Rogers J, & Kalin NH (2015). Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences. 112(29):9118-9122

Fox AS, Oler JA, Tromp DPM, Fudge J, & Kalin NH (2015). Extending the amygdala in theories of threat processing. Trends in Neurosciences. 38(5)

Heller AS, Fox AS, Wing EK, Mayer K, Vack NJ, Davidson RJ (2015). The neurodynamics of affect in the laboratory predicts persistence of real-world emotional responses. The Journal of Neuroscience. 35(29):10503–10509

Weng HY, Fox AS, Hessenthaler HC, Stodola DE, Davidson RJ (2015). The role of compassion in altruistic helping and punishment behavior. PLoS One. 10(12): e0143794

Kennis M, van Rooij SJH, Tromp DPM, Fox AS, Rademaker AR, Kahn RS, Kalin NH, Geuze E (2015). Dorsal cingulum differences related to treatment outcome in PTSD: A longitudinal diffusion tensor imaging study. Neuropsychopharmacology. 40(10):2434-42

Williams LE, Oler JA, Fox AS, McFarlin DR, Rogers GM, Davidson RJ, Pine DS, Jesson MAL, Kalin NH (2015). Fear of the Unknown: Uncertain Anticipation Reveals Amygdala Alterations in Childhood Anxiety Disorders. Neuropsychopharmacology. 40:1428-1435

Shackman AJ, Fox AS, Seminowicz DA (2015). The cognitive-emotional brain: Opportunitvnies and challenges for understanding neuropsychiatric disorders. (Commentary on: Précis on The Cognitive-Emotional Brain). Behavioral and Brain Sciences. 2015

2014

Roseboom PH, Nanda SA, Fox AS, Oler JA, Shackman AJ, Shelton SE, Davidson RJ, Kalin NH (2014). Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism. Biological Psychiatry. 76(11):850-857

Alisch RS, Chopra P, Fox AS, Chen K, White ATJ, Roseboom PH, Keles S, Kalin NH (2014). Differentially methylated plasticity genes in the amygdala of young primates are linked to anxious temperament, an at risk phenotype for anxiety and depressive disorders. Journal of Neuroscience. 34(47):15548-15556

Fox AS & Kalin NH (2014). A Translational Neuroscience Approach to Understanding the Development of Social Anxiety Disorder and Its Pathophysiology. American Journal of Psychiatry. 171(11):1162–1173

Birn RM*, Shackman AJ*, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine P, Slattery MJ, Davidson RJ, Fox AS, Kalin NH (2014). Evolutionarily-conserved prefrontal-amygdalar dysfunction in early-life anxiety. Molecular Psychiatry. 1-8

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Gluck MA, Davidson RJ (2014). Love to win or hate to lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward vs. punishment. Journal of Cognitive Neuroscience. 26(5):1039-48

2013

Shackman AJ*, Fox AS*, Oler JA, Shelton SE, Davidson RJ, Kalin NH (2013). Neural mechanisms underlying heterogeneity in the presentation of anxious temperament. Proceedings of the National Academy of Sciences. 120(15):6145-6150

Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Davidson RJ (2013). Dopamine asymmetries predict orienting bias in healthy individuals. Cerebral Cortex. 23(12):2899-904

Weng HY, Fox AS, Shackman AJ, Stodola DE, Caldwell JK, Olson MC, Rogers GM, Davidson RJ (2013). Compassion training alters altruism and neural responses to suffering. Psychological Science. 24(7):1171-1180

2012

Oler JA, Birn RM, Patriat R, Fox AS, Shelton SE, Burghy CA, Stodola DE, Essex MJ, Davidson RJ, Kalin NH (2012). Evidence for coordinated functional activity within the extended amygdala of non-human and human primates. Neuroimage. 61(4):1059-1066

Slagter HA, Tomer R, Christian BT, Fox AS Colzato LS, King CR, Murali D, Davidson RJ (2012). PET evidence for a role for striatal dopamine in the attentional blink: Functional implications. Journal of Cognitive Neuroscience. 24(9):1932-40

Rogers J, Raveendran M, Fawcett GL, Fox AS, Oler JA, Cheverud J, Muzny DM, Gibbs RA, Davidson RJ, Kalin NH (2012). CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression. Molecular Psychiatry. Advance Online Publication: 1–8

Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH (2012). Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proceedings of the National Academy of Sciences. 109(44):18108–18113

2011

Shackman AJ*, Salomons TV*, Slagter HA, Fox AS, Davidson RJ (2011). The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature Reviews Neuroscience. 12, 154-167

Adluru N, Zhang H, Fox AS, Shelton SE, Ennis CM, Bartosic AM, Oler JA, Tromp DPM, Zakszewski E, Gee JC, Kalin NH, Alexander AL (2011). A Diffusion Tensor Brain Template for Rhesus Macaques. Neuroimage. 59(1):306:318

2010

Jahn AL, Fox AS, Abercrombie HC, Shelton SE, Oakes TR, Davidson RJ, & Kalin NH (2010). Subgenual PFC Activity Predicts Individual Differences in HPA Activity Across Different Contexts. Biological Psychiatry. 67(2):175-181

Fox AS, Shelton SE, Oakes, TR, Davidson RJ, Kalin NH (2010). Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis. Journal of Neuroscience. 30(20):7023-7027

Oler JA*, Fox AS*, Shelton SE, Rogers J, Blangero J, Davidson RJ, Shelledy W, Oakes TR, Dyer T, Kalin NH (2010). Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature. 466, 864-868

2009

Christian BT, Vandehey NT, Fox AS, Murali D, Oakes TR, Nickles RJ, Shelton SE, Davidson RJ, Kalin NH (2009). The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging. Neuroimage. 44:1334-1344

Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH (2009). Serotonin transporter binding and genotype in the nonhuman primate using [C11]DASB PET. Neuroimage. 47: 1230-1236

Oler JA, Fox AS, Shelton SE, Christian BT, Murali D, Oakes TR, Davidson RJ, Kalin NH (2009). Serotonin Transporter Availability in the Amygdala and Bed Nucleus of the Stria Terminalis Predicts Anxious Temperament and Brain Glucose Metabolic Activity. Journal of Neuroscience. 29(32):9961-9966

2008

Kalin NH, Shelton SE, Fox AS, Rogers J, Oakes TR, Davidson RJ (2008). The Serotonin Transporter Genotype is Associated with Intermediate Brain Phenotypes that Depend on the Context of the Eliciting Stressor. Molecular Psychiatry. 13:1021-1027

Fox AS, Shelton SE, Oakes TR, Davidson RJ, Kalin NH (2008). Trait-like Brain Activity during Adolescence Predicts Anxious Temperament in Primates. PLoS One. 3(7): e2570

2007

Oakes TR, Fox AS, Johnstone T, Chung MK, Kalin NH, Davidson RJ (2007). Integrating VBM into the General Linear Model with Voxelwise Anatomical Covariates. NeuroImage. 34:500-508

2006

Johnstone T, Ores-Walsh KS, Greischar LL, Alexander AL, Fox AS, Davidson RJ, Oakes TR (2006). Motion correction and the use of motion covariates in multiple-subject fMRI analysis. Human Brain Mapping. 27(10):779-788

2005

Fox AS, Oakes TR, Shelton SE, Converse AK, Davidson RJ, Kalin NH (2005). Calling for Help is Independently Modulated by Brain Systems Underlying Goal-Directed Behavior and Threat Perception. Proceedings of the National Academy of Sciences. 102(11): 4180-4184

Oakes TR, Johnstone T, Ores Walsh KS, Greischar LL, Alexander AL, Fox AS, Davidson RJ (2005). Comparison of fMRI motion correction software tools. Neuroimage. 28(3): 521-744

Kalin NH, Shelton SE, Fox AS, Oakes TR, Davidson RJ (2005). Brain Regions Associated with the Expression and Contextual Regulation of Anxiety in Primates. Biological Psychiatry. 58: 796-804

2004

Nitschke JB, Nelson EE, Rusch BD, Fox AS, Oakes TR, Davidson RJ (2004). Orbitofrontal Cortex Tracks Positive Mood in Mothers Viewing Pictures of their Newborn Infants. NeuroImage. 21(2):583-92

Pizzagalli DA, Oakes TR, Fox AS, Chung MK, Larson CL, Abercrombie HC, Schaefer SM, Benca RM, Davidson RJ (2004). Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. Molecular Psychiatry. 9, 393-405