Category: publications

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2019

  • Fox AS*, Souaiaia T*, Oler JA, Kovner R, Mun J, Nguyen J, French DA, Riedel M, Fekete E, Rabska MR, Olsen ME, Brodsky EK, Alexander AL, Block WF, Roseboom PH, Knowles JA, Kalin NH (2019). Dorsal amygdala neurotrophin-3 decreases anxious temperament in primates. Biological Psychiatry. In Press

  • Golub MS, Hogrefe CE, Campos LJ, Fox AS (2019). Serotonin transporter (SERT) binding potentials in brain of juvenile monkeys one year after discontinuation of a two-year treatment with fluoxetine. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. In Press

  • Tromp DPM, Williams LE, Fox AS, Oler JA, Roseboom PH, Rogers GM, Benson BE, Alexander AL, Pine DS, Kalin NH (2019). Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders is Altered in Boys but not Girls. American Journal of Psychiatry. 176(3):208-216  Featured on the cover.

  • Hur J, Stockbridge MD, Fox AS, Shackman AJ (2019). Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework. Progress in Brain Research. 247

  • Kovner R, Fox AS, French DA, Roseboom PH, Oler JA, Fudge JL, Kalin NH (2019). Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala. Neuroscience. 400:157-168

  • Heller AS, Fox AS, Davidson RJ (2019). Parsing Affective Dynamics to Identify Risk for Mood and Anxiety Disorders. Emotion. 19(2):283-291

  • Hur J, Tillman RM, Fox AS, Shackman AJ (2019). The value of clinical and translational neuroscience approaches to psychiatric illness. Behavioral and Brain Sciences. 42, e11

  • 2018

  • Hur J, Kaplan CM, Smith JF, Bradford DE, Fox AS, Curtin JJ, Shackman AJ (2018). Acute alcohol administration dampens threat-related activation in the central extended amygdala. Scientific Reports. 12;8(1):16702

  • Fox AS*, Oler JA*, Birn RM, Shackman AJ, Alexander AL, & Kalin, NH (2018). Functional connectivity within the primate extended amygdala is heritable and associated with early-life anxious temperament. Journal of Neuroscience. 29;38(35):7611-7621 *These two authors contributed equally to this work.

  • Shackman AJ*, Fox AS* (2018). Getting Serious about Variation: Lessons for Clinical Neuroscience (A Commentary on "The Myth of Optimality in Clinical Neuroscience") . Trends in Cognitive Sciences. 22(5):368-369 *These two authors contributed equally to this work.

  • Tillman RM, Stockbridge MD, Nacewicz BM, Torrisi S, Fox AS, Smith JF, Shackman AJ (2018). Intrinsic functional connectivity of the central extended amygdala. Human Brain Mapping. 39(3):1291-1312

  • Fox AS (2018). The brain is organized to emote. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Fox AS*, Lapate RC, Davidson RJ & Shackman AJ* (2018). Epilogue—The nature of emotion: A research agenda for the 21st century. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press  *These two authors contributed equally to this work.

  • Fox AS (2018). On the significance of implicit emotional communication. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Okon-Singer H, Stout DM, Stockbridge MD, Gamer M, Fox AS & Shackman AJ (2018). The interplay of emotion and cognition. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Shackman AJ, Stockbridge MD, LeMay EP, & Fox AS (2018). The psychological and neurobiological bases of dispositional negativity. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Lapate RC & Fox AS (2018). Afterword: How and why are emotions communicated. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Fox AS & Shackman AJ (2018). Afterword: How are emotions physically embodied. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Lapate RC & Fox AS (2018). Afterword: What is the role of conscious awareness in emotion. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Fox AS & Lapate RC (2018). Afterword: How are emotions integrated into choice. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Shackman AJ, Lapate RC & Fox AS (2018). Afterword: How are emotions, mood, and temperament related. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Shackman AJ & Fox AS (2018). Afterword: What are the dimensions and bases for lasting individual differences in emotion. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Shackman AJ & Fox AS (2018). Afterword: How are emotions organized in the brain. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Fox AS & Lapate RC (2018). Afterword: When and in what ways are emotions adaptive and maladaptive. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Fox AS & Shackman AJ (2018). Afterword: How are emotions embodied in the social world. In Fox AS, Lapate RC, Shackman AJ & Davidson RJ (Eds.), The Nature of Emotion: Fundamental questions (2nd edition). New York: Oxford University Press

  • Shackman AJ, Weinstein J, Hudja SN, Bloomer C, Barstead MG, Fox AS & Lemay EP, Jr. (2018). Dispositional negativity in the wild: Social context governs momentary emotional experience. Emotion. 18(5):707-724

  • 2017

  • Shackman AJ*, Fox AS*, Oler JA, Shelton SE, Oakes TR, Davidson RJ, & Kalin, NH (2017). Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Molecular Psychiatry. 22(5):724-732  *These two authors contributed equally to this work.

  • Oler JA*, Tromp DPM*, Fox AS, Kovner R, Davidson RJ, Alexander AL, MacFarlin D, Birn R, Berg B, de Campo D, Fudge JL, & Kalin NH (2017). Brain Structure and Function. . 222(1):21-39  *These two authors contributed equally to this work.

  • 2016

  • Shackman AJ*, Fox AS* (2016). Contributions of the central extended amygdala to fear and anxiety. Journal of Neuroscience. 36(31):8050-8063

  • Shackman AJ, Tromp DPM, Stockbridge MD, Kaplan CM, Tillman RM, & Fox AS (2016). Dispositional negativity: An integrative psychological and neurobiological perspective. Psychological Bulletin. In Press

  • Shackman AJ*, Fox AS*, Oler JA, Shelton SE, Oakes TR, Davidson RJ, & Kalin, NH (2016). Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Molecular Psychiatry. In Press  *These two authors contributed equally to this work.

  • Shackman AJ, Kaplan CM, Stockbridge MD, Tillman RM, Tromp DPM, Fox AS, Gamer M (2016). The neurobiology of dispositional negativity and attentional biases to threat: Implications for understanding anxiety disorders in adults and youth. Journal of Experimental Psychopathology. In Press Special issue on “Risk and resilience in anxiety: Exploring the roles of attentional bias and attentional control in development” (Hadwin JA, Visu-Petra L, MacLeod C, Derakshan N & Muris P, Editors)

  • Kalin NH, Fox AS, Kovner R, Riedel MK, Feketa EM, Roseboom PH, Tromp DPM, Grabow BP, Brodsky EK, Olsen ME, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA (2016). Overexpressing Corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit. Biological Psychiatry. 80(5):345-55

  • Oler JA, Fox AS, Shackman AJ, Kalin NH (2016). The Central Nucleus of the Amygdala is a Critical Substrate for Individual Differences in Anxiety. Living without an amygdala (Amaral DG, Bauman M, & Adolphs R, Eds.). Guilford Press. 2016

  • Oler JA*, Tromp DPM*, Fox AS, Kovner R, Davidson RJ, Alexander AL, MacFarlin D, Birn R, Berg B, de Campo D, Fudge JL, & Kalin NH (2016). Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Structure and Function. 222(1):21-39  *These two authors contributed equally to this work.

  • 2015

  • Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander AL, Davidson RJ, Blangero J, Rogers J, & Kalin NH (2015). Intergenerational neural mediators of early-life anxious temperament. Proceedings of the National Academy of Sciences. 112(29):9118-9122  Also availible online at PNAS Online.

  • Fox AS, Oler JA, Tromp DPM, Fudge J, & Kalin NH (2015). Extending the amygdala in theories of threat processing. Trends in Neurosciences. 38(5)

  • Heller AS, Fox AS, Wing EK, Mayer K, Vack NJ, Davidson RJ (2015). The neurodynamics of affect in the laboratory predicts persistence of real-world emotional responses. The Journal of Neuroscience. 35(29):10503–10509

  • Weng HY, Fox AS, Hessenthaler HC, Stodola DE, Davidson RJ (2015). The role of compassion in altruistic helping and punishment behavior. PLoS One. 10(12): e0143794

  • Kennis M, van Rooij SJH, Tromp DPM, Fox AS, Rademaker AR, Kahn RS, Kalin NH, Geuze E (2015). Dorsal cingulum differences related to treatment outcome in PTSD: A longitudinal diffusion tensor imaging study. Neuropsychopharmacology. 40(10):2434-42

  • Williams LE, Oler JA, Fox AS, McFarlin DR, Rogers GM, Davidson RJ, Pine DS, Jesson MAL, Kalin NH (2015). Fear of the Unknown: Uncertain Anticipation Reveals Amygdala Alterations in Childhood Anxiety Disorders. Neuropsychopharmacology. 40:1428-1435

  • 2014

  • Roseboom PH, Nanda SA, Fox AS, Oler JA, Shackman AJ, Shelton SE, Davidson RJ, Kalin NH (2014). Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism. Biological Psychiatry. 76(11):850-857

  • Alisch RS, Chopra P, Fox AS, Chen K, White ATJ, Roseboom PH, Keles S, Kalin NH (2014). Differentially methylated plasticity genes in the amygdala of young primates are linked to anxious temperament, an at risk phenotype for anxiety and depressive disorders. Journal of Neuroscience. 34(47):15548-15556

  • Birn RM*, Shackman AJ*, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine P, Slattery MJ, Davidson RJ, Fox AS, Kalin NH (2014). Evolutionarily-conserved prefrontal-amygdalar dysfunction in early-life anxiety. Molecular Psychiatry. 1-8  *These two authors contributed equally to this work.

  • Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Gluck MA, Davidson RJ (2014). Love to win or hate to lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward vs. punishment. Journal of Cognitive Neuroscience. 26(5):1039-48

  • 2013

  • Shackman AJ*, Fox AS*, Oler JA, Shelton SE, Davidson RJ, Kalin NH (2013).  Neural mechanisms underlying heterogeneity in the presentation of anxious temperament.  Proceedings of the National Academy of Sciences. 120(15):6145-6150  *These two authors contributed equally to this work.

  • Tomer R, Slagter HA, Christian BT, Fox AS, King CR, Murali D, Davidson RJ (2013).  Dopamine asymmetries predict orienting bias in healthy individuals. Cerebral Cortex. 23(12):2899-904

  • Weng HY, Fox AS, Shackman AJ, Stodola DE, Caldwell JK, Olson MC, Rogers GM, Davidson RJ (2013).  Compassion training alters altruism and neural responses to suffering. Psychological Science. 24(7):1171-1180

  • 2012

  • Oler JA, Birn RM, Patriat R, Fox AS, Shelton SE, Burghy CA, Stodola DE, Essex MJ, Davidson RJ, Kalin NH (2012).  Evidence for coordinated functional activity within the extended amygdala of non-human and human primates.  Neuroimage. 61(4):1059-1066 

  • Slagter HA, Tomer R, Christian BT, Fox AS Colzato LS, King CR, Murali D, Davidson RJ (2012). PET evidence for a role for striatal dopamine in the attentional blink: Functional implications. Journal of Cognitive Neuroscience. 24(9):1932-40 

  • Rogers J, Raveendran M, Fawcett GL, Fox AS, Oler JA, Cheverud J, Muzny DM, Gibbs RA, Davidson RJ, Kalin NH (2012).  CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression.  Molecular Psychiatry. Advance Online Publication: 1–8  

  • Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH (2012). Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proceedings of the National Academy of Sciences. 109(44):18108–18113  Also availible online at PNAS Online.

  • 2011

  • Shackman AJ*, Salomons TV*, Slagter HA, Fox AS, Davidson RJ (2011).  The integration of negative affect, pain and cognitive control in the cingulate cortex.  Nature Reviews Neuroscience. 12, 154-167  *These two authors contributed equally to this work.

  • Adluru N, Zhang H, Fox AS, Shelton SE, Ennis CM, Bartosic AM, Oler JA, Tromp DPM, Zakszewski E, Gee JC, Kalin NH, Alexander AL (2011).  A Diffusion Tensor Brain Template for Rhesus Macaques.  Neuroimage. 59(1):306:318  

  • 2010

  • Jahn AL, Fox AS, Abercrombie HC, Shelton SE, Oakes TR, Davidson RJ, & Kalin NH (2010). Subgenual PFC Activity Predicts Individual Differences in HPA Activity Across Different Contexts.  Biological Psychiatry. 67(2):175-181  

  • Fox AS, Shelton SE, Oakes, TR, Davidson RJ, Kalin NH (2010).  Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis.  Journal of Neuroscience. 30(20):7023-7027  

  • Oler JA*, Fox AS*, Shelton SE, Rogers J, Blangero J, Davidson RJ, Shelledy W, Oakes TR, Dyer T, Kalin NH (2010).  Amygdalar and hippocampal substrates of anxious temperament differ in their heritability.  Nature. 466, 864-868  *These two authors contributed equally to this work.

  • 2009

  • Christian BT, Vandehey NT, Fox AS, Murali D, Oakes TR, Nickles RJ, Shelton SE, Davidson RJ, Kalin NH (2009).  The distribution of D2/D3 receptor binding in the adolescent rhesus monkey using small animal PET imaging.  Neuroimage. 44:1334-1344  

  • Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH (2009).  Serotonin transporter binding and genotype in the nonhuman primate using [C11]DASB PET.  Neuroimage. 47: 1230-1236

  • Oler JA, Fox AS, Shelton SE, Christian BT, Murali D, Oakes TR, Davidson RJ, Kalin NH (2009). Serotonin Transporter Availability in the Amygdala and Bed Nucleus of the Stria Terminalis Predicts Anxious Temperament and Brain Glucose Metabolic Activity.  Journal of Neuroscience. 29(32):9961-9966

  • 2008

  • Kalin NH, Shelton SE, Fox AS, Rogers J, Oakes TR, Davidson RJ (2008).  The Serotonin Transporter Genotype is Associated with Intermediate Brain Phenotypes that Depend on the Context of the Eliciting Stressor.  Molecular Psychiatry. 13:1021-1027  This article was featured on thecover of the November 2008 Issue of Molecular Psychiatry.

  • Fox AS, Shelton SE, Oakes TR, Davidson RJ, Kalin NH (2008).  Trait-like Brain Activity during Adolescence Predicts Anxious Temperament in Primates.  PLoS One. 3(7): e2570   Also availible online at PLoS One.

  • 2007

  • Oakes TR, Fox AS, Johnstone T, Chung MK, Kalin NH, Davidson RJ (2007).  Integrating VBM into the General Linear Model with Voxelwise Anatomical Covariates.  NeuroImage. 34:500-508  

  • 2006

  • Davidson RJ, Fox AS, Kalin NH (2006).  Neural bases of emotion regulation in non-human primates and humans.  In Gross and Gotlib (Eds.) Handbook of Emotion Regulation. New York: Guildford Press

  • Johnstone T, Ores-Walsh KS, Greischar LL, Alexander AL, Fox AS, Davidson RJ, Oakes TR (2006).  Motion correction and the use of motion covariates in multiple-subject fMRI analysis. Human Brain Mapping. 27(10):779-788  

  • 2005

  • Fox AS, Oakes TR, Shelton SE, Converse AK, Davidson RJ, Kalin NH (2005).  Calling for Help is Independently Modulated by Brain Systems Underlying Goal-Directed Behavior and Threat Perception.  Proceedings of the National Academy of Sciences. 102(11): 4180-4184   Also availible online at PNAS Online. This article was chosen to be highlighted in This week in PNAS.

  • Oakes TR, Johnstone T, Ores Walsh KS, Greischar LL, Alexander AL, Fox AS, Davidson RJ (2005).  Comparison of fMRI motion correction software tools.  Neuroimage. 28(3): 521-744 

  • Kalin NH, Shelton SE, Fox AS, Oakes TR, Davidson RJ (2005).  Brain Regions Associated with the Expression and Contextual Regulation of Anxiety in Primates.  Biological Psychiatry. 58: 796-804 

  • 2004

  • Nitschke JB, Nelson EE, Rusch BD, Fox AS, Oakes TR, Davidson RJ (2004).  Orbitofrontal Cortex Tracks Positive Mood in Mothers Viewing Pictures of their Newborn Infants.  NeuroImage. 21(2):583-92

  • Pizzagalli DA, Oakes TR, Fox AS, Chung MK, Larson CL, Abercrombie HC, Schaefer SM, Benca RM, Davidson RJ (2004).  Functional but not structural subgenual prefrontal cortex abnormalities in melancholia.  Molecular Psychiatry. 9, 393-405